The binding principles are: (1) In medical negligence cases, a plaintiff must prove on a balance of probabilities that the medical theory or treatment method on which the claim is based is valid before it can be established that failure to apply it caused the plaintiff's harm. (2) Factual 'but-for' causation must be established by proving on a balance of probabilities (not certainty or mathematical precision) that the defendant's conduct was probably a cause of the plaintiff's injury, applying a flexible common sense approach. (3) Expert opinion evidence based on the lowest class of scientific data (opinion based on small, non-rigorous samples), without independent corroboration, consensus in the medical literature, or general acceptance in medical practice, is insufficient to prove causation on a balance of probabilities. (4) An expert's opinion must be properly evaluated by examining the reasoning process, including the premises and the reliability of the underlying data - a bald statement of opinion has little probative value. (5) Without proof of factual causation, there is no need to examine wrongfulness and negligence.