The binding legal principles established are: (1) Under regulation 55 of the Private Hospital Regulations, a 'prospective proprietor' has the right to appeal against an administrative decision 'in respect of' such prospective proprietor, which includes the right to appeal against a composite decision that both refuses the appellant's own application and grants a competing application where the appellant is directly and causally affected by both aspects of the decision. (2) The phrase 'in respect of' in regulation 55 must be interpreted widely to include causal relationships and direct impacts, not merely direct party relationships, and must be interpreted consistently with constitutional rights to fair administrative action under sections 33 and 34 of the Constitution. (3) Under regulation 7(2)(i) of the Private Hospital Regulations, 'necessity' is the sole criterion for determining whether to grant 'permission in writing' to establish a private hospital at the approval stage. (4) Regulation 7 does not require an applicant to identify specific premises or a site at the 'prior approval' stage; it is sufficient to identify the area or locality with sufficient specificity to enable determination of necessity. The requirement to identify specific suitable premises only arises at the later registration stage under regulation 4. (5) An appeal is validly 'lodged' under regulations 56 and 57 when it is lodged with the Head of Department who submits it to the MEC; the duty to ensure procedural fairness by serving the appeal on affected parties rests with the decision-maker (the MEC), not the appellant. (6) Substitution orders under PAJA s 8(1)(c)(ii)(aa) are only appropriate in exceptional circumstances; where an administrative functionary is best equipped to make the decision and no exceptional circumstances exist, remittal is the appropriate remedy even where procedural unfairness is established.