In bail applications, the court must consider the cumulative effect of relevant factors rather than any single factor in isolation. These factors include: (1) the seriousness of the charges and likely penalties; (2) the strength of the State case versus the weaknesses and probability of the defense; (3) the accused's ability to flee, particularly through cross-border links and means of travel; (4) the risk of interference with witnesses, particularly where there is a power imbalance such as in employer-employee relationships. Where an accused faces a serious charge like murder with heavy penalties, the State case is strong, the defense appears improbable, the accused has cross-border business activities and links providing means and opportunity to abscond, and witnesses are the accused's employees creating interference risks, bail should be refused as it would not be in the interests of justice. Section 115C(2)(a)(iii) of the Criminal Procedure and Evidence Act, which places the burden on accused persons in specified offences to show they are suitable candidates for bail, remains valid law and is not unconstitutional merely because it requires the accused to counter compelling reasons for detention, as this is consistent with section 50(d) of the Constitution which permits continued detention where compelling reasons exist.